Week 10 NFL Betting Odds: Vegas Spreads & Totals

The dust from Week 9 of the NFL season has settled and the playoff picture is really starting to take shape. The biggest headline is probably that the Patriots finally lost (vs the Ravens), leaving just one undefeated team in the San Francisco 49ers (8-0). The Dolphins also finally won their first game of the season by defeating the Jets, leaving the Bengals as the last winless team in the league.

Week 10 NFL Vegas Game Lines: Point Spreads & Betting Totals

Week 10 of the season is an interesting one. There are a lot of lopsided matchups (three double-digit spreads), coupled with several games that are expected to be close (five matchups with spreads of 3 or less). There aren’t many impactful matchups as far as the playoffs are concerned, but the game we’re most interested in is the Seahawks at the 49ers on Monday Night Football.  The 49ers are undefeated, but the Seahawks have looked very good lately and this will be San Fran’s toughest contest to date.

Below you will find the latest odds for this week’s games, plus a betting preview for the matchup as they become available. Each preview give you a prediction against the spread or on the total by our staff writers. For free picks from our pros, you’ll want to visit our free NFL picks.

Line are current as of the publish date of the article, but they change frequently so the best place to compare the latest odds updates would be to see our live NFL odds here.

Week 10 NFL Odds (From 5Dimes)